PBPK in preterm and term neonates: a review
R Michelet, JV Bocxlaer… - Current pharmaceutical …, 2017 - ingentaconnect.com
Introduction: The neonatal population remains one of the populations in which appropriate
dosing regimens are still lacking, resulting in a large off-label or unlicensed use. Clinical …
dosing regimens are still lacking, resulting in a large off-label or unlicensed use. Clinical …
Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology
DE Watson, R Hunziker… - Experimental biology and …, 2017 - journals.sagepub.com
Microphysiological systems (MPS), which include engineered organoids (EOs), single
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …
organ/tissue chips (TCs), and multiple organs interconnected to create miniature in vitro …
Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
A Paini, JA Leonard, T Kliment, YM Tan… - Regulatory Toxicology …, 2017 - Elsevier
Physiologically based kinetic (PBK) models are used widely throughout a number of working
sectors, including academia and industry, to provide insight into the dosimetry related to …
sectors, including academia and industry, to provide insight into the dosimetry related to …
[HTML][HTML] Automated workflows for modelling chemical fate, kinetics and toxicity
JVS Benito, A Paini, AN Richarz, T Meinl, MR Berthold… - Toxicology in vitro, 2017 - Elsevier
Automation is universal in today's society, from operating equipment such as machinery, in
factory processes, to self-parking automobile systems. While these examples show the …
factory processes, to self-parking automobile systems. While these examples show the …
[PDF][PDF] Application of the Virtual Cell Based Assay for Simulation of in vitro Chemical fate following Acute Exposure
S Proenca, A Paini, E Joossens, JV Sala Benito… - 2017 - publications.jrc.ec.europa.eu
In order to reliably assess the risk of adverse systemic effects of chemicals by using in vitro
methods, there is a need to simulate their absorption, distribution, metabolism, and excretion …
methods, there is a need to simulate their absorption, distribution, metabolism, and excretion …
Non-focal non-thermal electrical methods for cancer treatment
QC Fernandez - 2017 - dialnet.unirioja.es
La mayoría de métodos físicos de ablación tumoral se basan en producir daño térmico de
manera focalizada. A pesar de ser considerada una alternativa habitual a la resección …
manera focalizada. A pesar de ser considerada una alternativa habitual a la resección …