An overview of neolignans of the genus Piper L.: isolation methods and biological activities

A Ladeira Macedo… - Mini Reviews in …, 2017 - ingentaconnect.com
Background: The genus Piper L. has the shikimic acid pathway predominantly expressed,
biosynthesizing many cinnamic acid derivatives (CAD). Objective: Neolignans comprise an …

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

TR Alexandre, ML Lima, MK Galuppo… - Journal of Venomous …, 2017 - SciELO Brasil
Background Major drawbacks of the available treatment against Chagas disease (American
trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the …

[HTML][HTML] The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis

N Miranda, H Volpato, JH da Silva Rodrigues… - … of Photochemistry and …, 2017 - Elsevier
Leishmaniasis is a disease caused by hemoflagellate protozoa, affecting millions of people
worldwide. The difficulties of treating patients with this parasitosis include the limited efficacy …

Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity

D Ramu, S Garg, R Ayana, AK Keerthana… - Biochemical …, 2017 - Elsevier
Visceral Leishmaniasis is a deadly parasitic disease caused by Leishmania donovani.
Paucity exists in the discovery of novel chemotherapeutics against Leishmaniasis. In this …

A3K2A3-induced apoptotic cell death of Leishmania amazonensis occurs through caspase- and ATP-dependent mitochondrial dysfunction

FP Garcia, J Henrique da Silva Rodrigues, ZU Din… - Apoptosis, 2017 - Springer
Leishmaniasis is a neglected tropical disease that affects millions of people worldwide.
Current therapies mainly rely on antimonial drugs that are inadequate because of their high …

Acyclic Sesquiterpenes from the Fruit Pericarp of Sapindus saponaria Induce Ultrastructural Alterations and Cell Death in Leishmania amazonensis

AL Moreira, DB Scariot, BL Pelegrini… - Evidence‐Based …, 2017 - Wiley Online Library
Previous studies reported antiprotozoal activities of Sapindus saponaria L. The aim of this
work was the evaluation of antileishmanial activity and mechanism of action of extract and …

[HTML][HTML] Ultrastructural and physiological changes induced by different stress conditions on the human parasite Trypanosoma cruzi

D Pérez-Morales, KDR Hernández, I Martínez… - Cell Stress and …, 2017 - Elsevier
Trypanosoma cruzi is the etiological agent of Chagas disease. The life cycle of this
protozoan parasite is digenetic because it alternates its different developmental forms …

Proteomic profile of Mycobacterium tuberculosis after eupomatenoid-5 induction reveals potential drug targets

LD Ghiraldi-Lopes, PAZ Campanerut-Sá… - Future …, 2017 - Taylor & Francis
Aim: We investigated a proteome profile, protein–protein interaction and morphological
changes of Mycobacterium tuberculosis after different times of eupomatenoid-5 (EUP-5) …

Novel therapeutic targets for human African trypanosomiasis

S Girdhar, A Girdhar, V Lather, D Pandita - Current Treatment Options in …, 2017 - Springer
Opinion statement Human African trypanosomiasis (HAT) or sleeping sickness is one of the
neglected tropic diseases caused by Trypanosoma brucei and endemic in sub-saharan …

[PDF][PDF] Research Article Acyclic Sesquiterpenes from the Fruit Pericarp of Sapindus saponaria Induce Ultrastructural Alterations and Cell Death in Leishmania …

AL Moreira, DB Scariot, BL Pelegrini, GL Pessini… - parasite, 2017 - academia.edu
Previous studies reported antiprotozoal activities ofSapindus saponariaL. The aim of this
work was the evaluation of antileishmanial activity and mechanism of action of extract and …