Creatine prevents corticosterone-induced reduction in hippocampal proliferation and differentiation: possible implication for its antidepressant effect

FL Pazini, MP Cunha, D Azevedo, JM Rosa… - Molecular …, 2017 - Springer
The benefits of creatine supplementation have been reported in a broad range of central
nervous system diseases, including depression, although the mechanisms underlying these …

Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test

FM Gonçalves, VB Neis, DK Rieger, TV Peres… - Journal of Neural …, 2017 - Springer
Glutamatergic system and mTOR signaling pathway have been proposed to be important
targets for pharmacological treatment of major depressive disorder. Previous studies have …

[PDF][PDF] An update on the neuroprotective effects of creatine in central nervous system diseases

MP Cunha - BIOSYNTHESIS, HEALTH EFFECTS AND CLINICAL …, 2017 - researchgate.net
Creatine (α-N-methylguanidino acetic acid) is a naturally occurring nitrogenous organic acid
synthesized in the kidneys, liver, pancreas and brain (in less quantity), or obtained from a …