Mitophagy is a selective mode of autophagy in which mitochondria are specifically targeted
for degradation at the autophagolysosome. Mitophagy is activated by stresses such as …

More recently, disease metastasis and relapse in many cancer patients several years (even
some decades) after surgical remission are regarded as tumor dormancy. However, the …

Three-prime repair exonuclease 1 knockout (Trex1−/−) mice suffer from systemic
inflammation caused largely by chronic activation of the cyclic GMP-AMP synthase …

Metastasis causes more than 90% of cancer-related deaths and most prostate cancer (PCa)
patients also die from metastasis. The 'metastatic cascade'is a complex biological process …

Bladder cancer is a challenging and fatal malignancy and the improvement in prognosis is
limited over years. Deep understanding the mechanism of bladder cancer tumorigenesis …

The innate immune system is responsible for sensing pathogen-associated molecular
patterns (PAMPs) or danger-associated molecular patterns (DAMPs) by several types of …

Dormant leukaemia initiating cells in the bone marrow niche are a crucial therapeutic target
for total eradication of acute myeloid leukaemia. To study this cellular subset we created and …

Background: The purpose of the present study was to investigate the function of TANK-
binding kinase 1 (TBK1) in head and neck squamous cell carcinoma (HNSCC) …

Skeletal metastasis is a lethal component of many advanced cancers including prostate, the
second most common cancer among men. Patients whose prostate cancer is localized and …