Seletalisib: characterization of a novel, potent, and selective inhibitor of PI3Kδ
RA Allen, DC Brookings, MJ Powell, J Delgado… - … of Pharmacology and …, 2017 - ASPET
Phosphoinositide 3-kinases (PI3K) are key signaling enzymes regulating cellular survival,
development, and function. Expression of the PI3K δ isoform is largely restricted to …
development, and function. Expression of the PI3K δ isoform is largely restricted to …
[HTML][HTML] Dihydroartemisinin attenuates autoimmune thyroiditis by inhibiting the CXCR3/PI3K/AKT/NF-κB signaling pathway
H Liu, Q Tian, X Ai, Y Qin, Z Cui, M Li, J Yang, D Zhai… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Dihydroartemisinin (DHA) is the first generation of naturally occurring artemisinin derivatives
with antimalarial activity. Recent research showed that this drug also features …
with antimalarial activity. Recent research showed that this drug also features …
Phosphoinositol 3-phosphate acts as a timer for reactive oxygen species production in the phagosome
ZM Song, L Bouchab, E Hudik, R Le Bars… - Journal of Leucocyte …, 2017 - academic.oup.com
Production of reactive oxygen species (ROS) in the phagosome by the NADPH oxidase is
critical for mammalian immune defense against microbial infections and phosphoinositides …
critical for mammalian immune defense against microbial infections and phosphoinositides …
Rapamycin alleviates inflammation and muscle weakness, while altering the Treg/Th17 balance in a rat model of myasthenia gravis
F Jing, F Yang, F Cui, Z Chen, L Ling… - Bioscience …, 2017 - portlandpress.com
Myasthenia gravis (MG) is an autoimmune disease commonly treated with
immunosuppressants. We evaluated the novel immunosuppressant, rapamycin (RAPA), in a …
immunosuppressants. We evaluated the novel immunosuppressant, rapamycin (RAPA), in a …
Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase-4 (DPP-4), antagonists of the C–C Chemokine Receptor …
C Schwehm, B Kellam, AE Garces, SJ Hill… - Journal of Medicinal …, 2017 - ACS Publications
A novel molecular scaffold has been synthesized, and its incorporation into new analogues
of biologically active molecules across multiple target classes will be discussed. In these …
of biologically active molecules across multiple target classes will be discussed. In these …
Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells
P Jia, Y Hu, G Li, Y Sun, J Zhao, J Fu, C Lu… - Acta Cirurgica …, 2017 - SciELO Brasil
Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with
the abnormal deposition of extracellular matrix regulated by connective tissue growth factor …
the abnormal deposition of extracellular matrix regulated by connective tissue growth factor …
Estudio de lípidos aislados de microalgas y polifenoles en modelos inflamatorios de piel.
AM Rodríguez Luna - 2017 - idus.us.es
Estudio de lípidos aislados de microalgas y polifenoles en modelos inflamatorios de piel
Page 1 Universidad de Sevilla Facultad de farmacia Departamento de farmacología …
Page 1 Universidad de Sevilla Facultad de farmacia Departamento de farmacología …
Pharmacokinetics and Bronchopulmonary Disposition of PI3Kδ Inhibitor IC87114 after Intratracheal Administration in a Severe Asthma Model.
A Marahatta, IH Baek, JS Pyo… - Indian Journal of …, 2017 - search.ebscohost.com
Type 2 helper T cell-predominant asthma is a refractory type of asthma that has motivated
biomedical industries to develop novel drugs. The phosphoinositide 3-kinase pathway has …
biomedical industries to develop novel drugs. The phosphoinositide 3-kinase pathway has …
[图书][B] Role of TLRs, Hippo-YAP1 Signaling, and microRNAs in Cardiac Repair and Regeneration of Damaged myocardium During Ischemic Injury
X Wang - 2017 - search.proquest.com
Cardiovascular disease is a leading cause of death in the United States. Toll-like receptor
(TLR)-mediated pathways have been demonstrated to play a role in myocardial …
(TLR)-mediated pathways have been demonstrated to play a role in myocardial …