Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system
(CNS) in which autoreactive immune cells recognizing myelin antigens lead to …

Introduction: Neuroinflammation is a crucial mechanism in the pathophysiology of
neurodegenerative diseases pathophysiology. Cerebrospinal fluid (CSF) YKL-40–an …

Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by
inflammatory, cancer and stem cells. Its physiological role is not completely understood but …

Objective: To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-
like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). Methods: A cohort …

Cerebrospinal fluid (CSF) biomarkers can reflect different aspects of the pathophysiology of
relapsing‐remitting multiple sclerosis (RRMS). Understanding the impact of different disease …

Background The innate immune system is known to be involved early in the pathogenesis of
Alzheimer's disease (AD) and other neurodegenerative disorders. The inflammatory …

Background: The disease-modifying therapies (DMTs) in relapsing-remitting multiple
sclerosis (RRMS) vary in their mode of action and when therapies are changed, the …

Introduction: Intrathecal B-lymphocyte activation is a hallmark of multiple sclerosis (MS), a
multi-factorial inflammatory-demyelinating disease of the central nervous system. Such …

Progressive multiple sclerosis (MS) is characterized by insidious clinical worsening that is
difficult to accurately quantify and predict. Biofluid markers and electrophysiological …

The rapidly growing number of biomedical studies supported by mass spectrometry based
quantitative proteomics data has made it increasingly difficult to obtain an overview of the …