While a large number of studies has examined the efficacy of opioid-sparing analgesics in
adult surgical populations, fewer studies are available to guide postoperative pain treatment …

Childhood burns are a profoundly traumatic and painful experience. Despite recognition of
the prevalence of burn injuries in children and the severity of the associated pain, burn pain …

Pain management in the neonatal ICU remains challenging for many clinicians and in many
complex care circumstances. The authors review general pain management principles and …

The majority of marketed drugs remain understudied in some patient populations such as
pregnant women, paediatrics, the obese, the critically-ill, and the elderly. As a consequence …

Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant
women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a …

Objective: To assess the opioid and benzodiazepine usage in a level IV NICU after
implementation of pain guidelines. Study design: Guidelines were developed for infants …

Background Experimental studies have shown that neonatal exposure to stress, pain,
opioids and anaesthetics may cause histologic and morphologic changes in the central …

Introduction: Pharmacologic pain management in newborns and infants is often based on
limited scientific data. To close the knowledge gap, drug-related research in this population …

Objective The mainstay of pain treatment after paediatric cardiac surgery is the use of
opioids. Current guidelines for its optimal use are based on small, non-randomised clinical …

Background We previously showed the practical and ethical feasibility of using [14 C]-
microdosing for pharmacokinetic studies in children. We now aimed to show that this …