CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Myeloid cells in the central nervous system (CNS) represent a heterogeneous class of
innate immune cells that contribute to the maintenance of tissue homeostasis differentially …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Microglia are resident immune cells in the central nervous system (CNS), which are
essential for immune defence and critically contribute to neuronal functions during …

Microglia are emerging as a key cell type in neurodegenerative diseases, yet human
microglia are challenging to study in vitro. We developed an in vitro cell model system …

Microglia, mainly known for their role in innate immunity and modulation of
neuroinflammation, play an active role in central nervous system development and …

Friedreich's ataxia (FRDA) is an incurable autosomal recessive neurodegenerative disease
caused by reduced expression of the mitochondrial protein frataxin due to an intronic GAA …

Peripheral inflammation is known to trigger neuroinflammation and neurodegenerative
disease. However, the key components during the propagation of inflammation from the …

The commonest severe inherited bleeding disorder in all ethnic groups worldwide is
hemophilia A, followed by hemophilia B. These are X-linked recessive disorders that result …

Microglia are immune cells in the central nervous system (CNS) that originate from the yolk
sac in an embryo. The renewal of the microglia pool in the adult eye consists of two …