Epidemiology and outcome of glioblastoma
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. With an
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …
[HTML][HTML] Glioma subclassifications and their clinical significance
R Chen, M Smith-Cohn, AL Cohen, H Colman - Neurotherapeutics, 2017 - Elsevier
The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014
QT Ostrom, H Gittleman, P Liao… - Neuro …, 2017 - academic.oup.com
Background CBTRUS is a unique professional research organization that focuses
exclusively on providing high quality statistical data on the population-based incidence of …
exclusively on providing high quality statistical data on the population-based incidence of …
Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …
Comprehensive and integrative genomic characterization of hepatocellular carcinoma
A Ally, M Balasundaram, R Carlsen, E Chuah, A Clarke… - Cell, 2017 - cell.com
Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …
The whole-genome landscape of medulloblastoma subtypes
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …
debilitating effects on the developing child, and highlight the need for molecularly targeted …
m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program
The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
Advances in the molecular genetics of gliomas—implications for classification and therapy
G Reifenberger, HG Wirsching… - Nature reviews Clinical …, 2017 - nature.com
Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …
alterations and epigenetic profiles associated with different types of gliomas. These …
Cancer-associated pathways and biomarkers of venous thrombosis
Y Hisada, N Mackman - Blood, The Journal of the American …, 2017 - ashpublications.org
Cancer patients have an increased risk of venous thromboembolism (VTE). In this review,
we summarize common and cancer type–specific pathways of VTE in cancer patients …
we summarize common and cancer type–specific pathways of VTE in cancer patients …
[HTML][HTML] Glioblastoma targeted therapy: updated approaches from recent biological insights
Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …
representing a highly heterogeneous group of neoplasms that are among the most …