Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Abstract Trisomy 21 (T21) causes Down syndrome (DS), but the mechanisms by which T21
produces the different disease spectrum observed in people with DS are unknown. We …
produces the different disease spectrum observed in people with DS are unknown. We …
[HTML][HTML] Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
M Zhou, J Luo, M Chen, H Yang, RM Learned… - Journal of …, 2017 - Elsevier
Background & Aims Bile acid nuclear receptor farnesoid X receptor (FXR) is a key molecular
mediator of many metabolic processes, including the regulation of bile acid, lipid and …
mediator of many metabolic processes, including the regulation of bile acid, lipid and …
[PDF][PDF] Regulation of receptor binding specificity of FGF9 by an autoinhibitory homodimerization
Y Liu, J Ma, A Beenken, L Srinivasan, AV Eliseenkova… - Structure, 2017 - cell.com
The epithelial fibroblast growth factor 9 (FGF9) subfamily specifically binds and activates the
mesenchymal" c" splice isoform of FGF receptors 1–3 (FGFR1–3) to regulate organogenesis …
mesenchymal" c" splice isoform of FGF receptors 1–3 (FGFR1–3) to regulate organogenesis …
FGF9 mutation causes craniosynostosis along with multiple synostoses
M Rodriguez‐Zabala, M Aza‐Carmona… - Human …, 2017 - Wiley Online Library
Craniosynostosis is commonly caused by mutations in fibroblast growth factor receptors
(FGFRs), highlighting the essential role of FGF‐mediated signaling in skeletal development …
(FGFRs), highlighting the essential role of FGF‐mediated signaling in skeletal development …
Parallels and distinctions in FGFR, VEGFR, and EGFR mechanisms of transmembrane signaling
S Sarabipour - Biochemistry, 2017 - ACS Publications
Receptor tyrosine kinase (RTK) signal transduction is essential in human skeletal, nervous,
and vascular development, in homeostasis, and in disease. RTKs are activated by …
and vascular development, in homeostasis, and in disease. RTKs are activated by …
[PDF][PDF] 致死性侏儒症Ⅰ 型高发突变发生机制浅析
姜煜， 郭东炜， 郭奕斌 - 分子诊断与治疗杂志, 2017 - core.ac.uk
致死性侏儒症(thanatophoric dysplasia, TD) 是重型短肢畸形病中相对常见的致死性遗传性骨病
, 分为TD⁃ I 和TD⁃ II 2 型, 它们都是由于FGFR3 基因发生致死突变所致. TD⁃ I …
, 分为TD⁃ I 和TD⁃ II 2 型, 它们都是由于FGFR3 基因发生致死突变所致. TD⁃ I …
[PDF][PDF] Master of Veterinary
P Joshi - 2017 - krishikosh.egranth.ac.in
I avail this opportunity to express my deep sense of gratitude and sincere regards to Dr. NS
Jadon, Professor and Head, Department of Veterinary Surgery and Radiology for his …
Jadon, Professor and Head, Department of Veterinary Surgery and Radiology for his …
[图书][B] Increased FGF and HH Signaling Impairs Craniofacial and Limb Morphogenesis
LG Schmidt - 2017 - search.proquest.com
Tight regulation of signaling pathways during embryogenesis is required for normal
development. In contrast, aberrations in signaling frequently result in fetal and infant …
development. In contrast, aberrations in signaling frequently result in fetal and infant …