Generating a precise cellular and molecular cartography of the human embryo is essential
to our understanding of the mechanisms of organogenesis in normal and pathological …

End-stage renal disease (ESRD) is characterized by the progressive deterioration of renal
function that may compromise different tissues and organs. The major treatment indicated for …

The kidney contains the functional units, the nephrons, surrounded by the renal interstitium.
Previously we discovered that, once Six2-expressing nephron progenitor cells and Foxd1 …

Animal fetuses and embryos may have applications in the generation of human organs.
Progenitor cells may be an appropriate cell source for regenerative organs because of their …

Podocytes present a unique 3D architecture specialized for glomerular filtration. However,
several 3D morphological aspects on podocyte development remain partially understood …

The basal, intermediate, and superficial cell layers of the urothelium undergo rapid and
complete recovery following acute injury; however, the effects of chronic injury on urothelial …

New nephrons are induced by the interaction between mesenchymal progenitor cells and
collecting duct tips, both of which are located at the outer edge of the kidney. This leading …

The formation of the proper number of nephrons requires a tightly regulated balance
between renal progenitor cell self-renewal and differentiation. The molecular pathways that …

Prostate organogenesis involves epithelial growth controlled by inductive signalling from
specialised mesenchymal subsets. To identify pathways active in mesenchyme we used …

The Wnt5a null mouse is a complex developmental model which, among its several
posterior-localized axis defects, exhibits multiple kidney phenotypes, including duplex …