Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms

CR Lee, JH Lee, KS Park, JH Jeon, YB Kim… - Frontiers in cellular …, 2017 - frontiersin.org
Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised
individuals responsible for community-acquired and nosocomial infections, including …

Hypervirulence and hypermucoviscosity: Two different but complementary Klebsiella spp. phenotypes?

JC Catalán-Nájera, U Garza-Ramos… - Virulence, 2017 - Taylor & Francis
Since the hypermucoviscous variants of Klebsiella pneumoniae were first reported, many
cases of primary liver abscesses and other invasive infections caused by this pathogen have …

Bacterial and fungal endophthalmitis

ML Durand - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Endophthalmitis is a severe eye infection that may result in permanent loss of useful vision
in the affected eye. Most cases are exogenous and occur as a complication of cataract …

Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China

L Zhan, S Wang, Y Guo, Y Jin, J Duan, Z Hao… - Frontiers in cellular …, 2017 - frontiersin.org
Hypervirulent and multidrug resistant Klebsiella pneumoniae strains pose a significant threat
to the public health. In the present study, 21 carbapenem-resistant K. pneumoniae isolates …

Microbiological and Clinical Characteristics of Hypermucoviscous Klebsiella pneumoniae Isolates Associated with Invasive Infections in China

Y Guo, S Wang, L Zhan, Y Jin, J Duan, Z Hao… - Frontiers in cellular …, 2017 - frontiersin.org
A distinctive syndrome caused by hypermucoviscous Klebsiella pneumoniae (HMKP)
including pyogenic liver abscess (PLA) is now becoming a globally emerging disease. In the …

Two T7-like bacteriophages, K5-2 and K5-4, each encodes two capsule depolymerases: isolation and functional characterization

PF Hsieh, HH Lin, TL Lin, YY Chen, JT Wang - Scientific Reports, 2017 - nature.com
Two Klebsiella bacteriophages K5-2 and K5-4, which are able to infect and grow on either
capsular types K30/K69 and K5 or K8 and K5 of Klebsiella strains, were isolated and …

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae

ME Pennini, A De Marco, M Pelletier, J Bonnell… - Nature …, 2017 - nature.com
Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these
pathogens are so successful is not fully understood. Robust antibacterial vaccines have …

Colibactin Contributes to the Hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in Mouse Meningitis Infections

MC Lu, YT Chen, MK Chiang, YC Wang… - Frontiers in cellular …, 2017 - frontiersin.org
Klebsiella pneumoniae is the most common pathogen of community-acquired meningitis in
Taiwan. However, the lack of a physiologically relevant meningitis model for K. pneumoniae …

Antibody-based immunotherapy to treat and prevent infection with hypervirulent Klebsiella pneumoniae

E Diago-Navarro, I Calatayud-Baselga… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
ABSTRACT Hypervirulent Klebsiella pneumoniae (hv Kp) strains are predicted to become a
major threat in Asia if antibiotic resistance continues to spread. Anticapsular antibodies …

Klebsiella pneumoniae Isolates from Meningitis: Epidemiology, Virulence and Antibiotic Resistance

YH Ku, YC Chuang, CC Chen, MF Lee, YC Yang… - Scientific reports, 2017 - nature.com
Klebsiella pneumoniae (KP) resistance to broad-spectrum cephalosporin (BSC) in
meningitis is important because of limited therapeutic options. To investigate the antibiotic …