Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The
functional components are the protective mucous layer, the airway surface liquid layer, and …

The past decade has witnessed a consolidation and refinement of the extraordinary
progress made in taste research. This Review describes recent advances in our …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …

Bitter taste is an innately aversive taste modality that is considered to protect animals from
consuming toxic compounds. Yet, bitterness is not always noxious and some bitter …

We show that mucociliary membranes of animal epithelia can create fluid-mechanical
microenvironments for the active recruitment of the specific microbiome of the host. In …

Since the beginning of the millennium, research in primary cilia has revolutionized our way
of understanding how cells integrate and organize diverse signaling pathways during …

It is increasingly recognized that chronic rhinosinusitis (CRS) comprises a spectrum of
different diseases with distinct clinical presentations and pathogenic mechanisms. Defining …

Cilia are organelles specialized for movement and signaling. To infer when during evolution
signaling pathways became associated with cilia, we characterized the proteomes of cilia …

G-protein-coupled receptors (GPCRs) are the largest and most versatile family of signaling
receptors in humans. They respond to diverse external signals, such as photons, proteins …