Recent progress in Alzheimer's disease research, part 2: genetics and epidemiology
This is the second part of a three-part review series reviewing the most important advances
in Alzheimer's disease (AD) research since 2010. This review covers the latest research on …
in Alzheimer's disease (AD) research since 2010. This review covers the latest research on …
Primary and secondary prevention trials in Alzheimer disease: looking back, moving forward
D Hsu, GA Marshall - Current Alzheimer Research, 2017 - ingentaconnect.com
The field of Alzheimer disease (AD) prevention has been a culmination of basic science,
clinical, and translational research. In the past three years since the new 2011 AD diagnostic …
clinical, and translational research. In the past three years since the new 2011 AD diagnostic …
Epigenomics of Alzheimer's disease
Alzheimer's disease (AD) is a large and growing public health problem. It is characterized by
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …
the accumulation of amyloid-β peptides and abnormally phosphorylated tau proteins that are …
Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive …
A Lacour, A Espinosa, E Louwersheimer… - Molecular …, 2017 - nature.com
Few data are available concerning the role of risk markers for Alzheimer's disease (AD) in
progression to AD dementia among subjects with mild cognitive impairment (MCI). We …
progression to AD dementia among subjects with mild cognitive impairment (MCI). We …
Mitochondria, cybrids, aging, and Alzheimer's disease
RH Swerdlow, S Koppel, I Weidling, C Hayley… - Progress in molecular …, 2017 - Elsevier
Mitochondrial and bioenergetic function change with advancing age and may drive aging
phenotypes. Mitochondrial and bioenergetic changes are also documented in various age …
phenotypes. Mitochondrial and bioenergetic changes are also documented in various age …
Alzheimer disease: scientific breakthroughs and translational challenges
RJ Caselli, TG Beach, DS Knopman… - Mayo Clinic …, 2017 - Elsevier
Alzheimer disease (AD) was originally conceived as a rare disease that caused presenile
dementia but has come to be understood as the most prevalent cause of dementia at any …
dementia but has come to be understood as the most prevalent cause of dementia at any …
Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes
The last decade has witnessed a proliferation of neuroimaging studies characterising brain
changes associated with Alzheimer's disease (AD), where both widespread atrophy and …
changes associated with Alzheimer's disease (AD), where both widespread atrophy and …
[HTML][HTML] The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of …
PA Larsen, MW Lutz, KE Hunnicutt, M Mihovilovic… - Alzheimer's & …, 2017 - Elsevier
It is hypothesized that retrotransposons have played a fundamental role in primate evolution
and that enhanced neurologic retrotransposon activity in humans may underlie the origin of …
and that enhanced neurologic retrotransposon activity in humans may underlie the origin of …
Genetics of vascular dementia–review from the ICVD working group
MA Ikram, A Bersano, R Manso-Calderón, JP Jia… - BMC medicine, 2017 - Springer
Background Vascular dementia is a common disorder resulting in considerable morbidity
and mortality. Determining the extent to which genes play a role in disease susceptibility and …
and mortality. Determining the extent to which genes play a role in disease susceptibility and …
[HTML][HTML] The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease
K Zeitlow, L Charlambous, I Ng, S Gagrani… - … et Biophysica Acta (BBA …, 2017 - Elsevier
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated
with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the …
with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the …