3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …

Classical genetic approaches for interpreting variants, such as case-control or co-
segregation studies, require finding many individuals with each variant. Because the …

During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-
structured precursors into mature miRNAs. These processing steps can be …

Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs), have
emerged as promising biomarker sources for non-invasive detection of cancer. Here we …

The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1
to regulate the translation of 5'TOP mRNAs such as those encoding ribosome proteins (RP) …

Our ability to predict protein expression from DNA sequence alone remains poor, reflecting
our limited understanding of cis-regulatory grammar and hampering the design of …

A goal of human genetics studies is to determine the mechanisms by which genetic variation
produces phenotypic differences that affect human health. Efforts in this respect have …

RGG/RG domains are the second most common RNA binding domain in the human
genome, yet their RNA-binding properties remain poorly understood. Here, we report a …

The lack of tools to identify causative variants from sequencing data greatly limits the
promise of precision medicine. Previous studies suggest that one-third of disease …