Integrins constitute a large group of adhesion receptors that are formed as heterodimers of α
and β subunits. Their presence and activation status on the surface of leukocytes modulate a …

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe
infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been …

Our group recently identified 16 genes whose peripheral blood expression levels are
differentially regulated in acute ischemic stroke. The purpose of this study was to determine …

Candida albicans infection produces elongated hyphae resistant to phagocytic clearance
compelling alternative neutrophil effector mechanisms to destroy these physically large …

Paracoccidioides brasiliensis is one of the etiological agents of the human systemic mycosis
paracoccidioidomycosis. Protease-activated receptors (PARs) are expressed in many cell …

The host injury involved in multiorgan system failure during severe inflammation is
mediated, in part, by massive infiltration and sequestration of hyperactive neutrophils in the …

Neutrophils respond to bacterial LPS through Toll-like receptor 4 (TLR4), which activates or
potentiates immune defensive functions and prolongs cell survival. Activation of TLR4 …

Sepsis represents a dysregulated systemic acute inflammatory response to severe infection.
Despite efforts to develop supportive sepsis therapies, none has been approved that …

Sepsis remains an important health problem worldwide and in Mexico. Mortality rates for this
disease reach up to 30% of total cases in our country. This is a consequence of the …