Biophysical stimuli presented to cells via microenvironmental properties (eg, alignment and
stiffness) or external forces have a significant impact on cell function and behavior. Recently …

The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and
inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and …

Abstract Nesprins-1 and-2 are highly expressed in skeletal and cardiac muscle and together
with SUN (Sad1p/UNC84)-domain containing proteins and lamin A/C form the LInker of …

The exceptionally large SYNE1 (spectrin repeat-containing nuclear envelope protein 1)
gene encodes different nesprin-1 isoforms, which are differentially expressed in striated …

Alteration of the nuclear Ca2+ transient is an early event in cardiac remodeling. Regulation
of the nuclear Ca2+ transient is partly independent of the cytosolic Ca2+ transient in …

Emerin is an inner nuclear membrane protein that is involved in maintaining the mechanical
integrity of the nuclear membrane. Increasing evidence supports the involvement of emerin …

In animals, it is now well established that forces applied at the cell surface are propagated
through the cytoskeleton to the nucleus, leading to deformations of the nuclear structure and …

The cytoskeleton provides structure and plays an important role in cellular function such as
migration, resisting compression forces, and transport. The cytoskeleton also reacts to …

The nuclear envelope forms the interface between the nucleus and the cytoplasm. The
nuclear envelope consists of the two concentric lipid membranes, the nuclear pores and the …

Many tissue-restricted diseases are linked to mutations in lamins and nuclear envelope
transmembrane proteins (NETs). How these mutations in ubiquitously expressed proteins …