Tryptophan-Containing Non-Cationizable Opioid Peptides – a new chemotype with unusual structure and in vivo activity
RD Marco, L Gentilucci - Future Medicinal Chemistry, 2017 - Future Science
Recently, a new family of opioid peptides containing tryptophan came to the spotlight for the
absence of the fundamental protonable tyramine 'message'pharmacophore. Structure …
absence of the fundamental protonable tyramine 'message'pharmacophore. Structure …
Azepinone-Constrained Amino Acids in Peptide and Peptidomimetic Design
S Ballet, K Guillemyn, O Van der Poorten, B Schurgers… - Peptidomimetics I, 2017 - Springer
Side chain topography of amino acids that are part of a peptide's pharmacophore represents
a crucial structural feature in peptidomimetic design. Constraining the side chain dihedral …
a crucial structural feature in peptidomimetic design. Constraining the side chain dihedral …
[PDF][PDF] A Brief Survey on Recent Endomorphin-1 and Endomorphin-2 Analogues
R De Marco - J Biochem Chem Sci, 2017 - researchgate.net
The neurophysiological distribution of the Endomorphins (EMs), ie, Endomorphin-1 (EM1)
and Endomorphin-2 (EM2), reflects their potential role in many major biological processes …
and Endomorphin-2 (EM2), reflects their potential role in many major biological processes …