Rotavirus gastroenteritis is a leading global cause of mortality and morbidity in young
children due to diarrhea and dehydration. Over 85% of deaths occur in developing …

Herein we describe a formulation of self-encapsulating poly (lactic-co-glycolic acid)(PLGA)
microspheres for vaccine delivery. Self-healing encapsulation is a novel encapsulation …

Background: Group A streptococcus (GAS) is an exclusively human pathogenic bacteria. A
delay in treatment of GAS infection often lead to severe diseases such as rheumatic heart …

Along with the implementation of clean water and sanitation, vaccines have contributed
significantly to global disease reduction and eradication, saving millions of lives. Originating …

Previous study revealed that a specific lignin-carbohydrate preparation, named as lignin-rich
enzyme lignin (LREL) derived from plant husk, is a novel toll-like receptor 4 ligand and …

Double mutant heat-labile toxin (dmLT) is a promising adjuvant for oral vaccine
administration. The aims of our study were to develop sensitive methods to detect low …

A novel protein adjuvant double-mutant Escherichia coli heat-labile toxin, LT
(R192G/L211A) or dmLT, is in preclinical and early clinical development with various …

Objective It has previously been shown that oral immunization with the 40-kDa outer
membrane protein of Porphyromonas gingivalis (40k-OMP) and CpG oligodeoxynucleotides …

The membrane (M) protein is the most abundant component of the porcine transmissible
gastroenteritis virus (TGEV) particle. To exploit the possibility of using RNA interference …

The past quarter of a century has been witness to a devastating pandemic taking the lives of
more than 25 million people and to date leaving more than 40 million infected with a virus …