Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …

Viscosity, as one of the major factors of intracellular microenvironment, influences the
function of proteins. To detect local micro-viscosity of a protein, it is a precondition to apply a …

The short-chain and n-3 polyunsaturated fatty acids exhibit anticancer properties, and they
may mutually interact within the colon. However, the molecular mechanisms of their action in …

Chromatin modification is traditionally assessed in biochemical assays that provide average
measurements of static events given that the analysis requires components from many cells …

Cajal bodies (CBs) are important compartments containing accumulated proteins that
preferentially regulate RNA‐related nuclear events, including splicing. Here, we studied the …

Diplomová práce je zaměřena na studium histonů H1, H2B, H3. 3 a H4, laminů A a proteinů
HP1β a 53BP1 účastnících se reparačních drah DNA. V experimentech byly použity …