Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and
may have impacted the prebiotic chemistry that led to life. However, it is unclear whether iron …

The evolutionary origins of the Krebs cycle (tricarboxylic acid cycle) are not currently clear.
Despite the existence of a simple non-enzymatic Krebs cycle catalyst being dismissed only a …

Iron-sulfur clusters are indispensable to extant metabolism and are thought to have had an
ancient role in mediating the chemical reactions that led to life. However, there has been no …

Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and
may have impacted the prebiotic chemistry that led to life. However, it is unclear whether iron …

In the hyperthermophilic autotrophic anaerobe, Methanocaldococcus jannaschii, many of
the canonical biosynthetic pathways are replaced with novel routes. Such is the case with …