Radiogenomic analysis of oncological data: a technical survey

M Incoronato, M Aiello, T Infante, C Cavaliere… - International journal of …, 2017 - mdpi.com
In the last few years, biomedical research has been boosted by the technological
development of analytical instrumentation generating a large volume of data. Such …

The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention

KE Pendleton, B Chen, K Liu, OV Hunter, Y Xie, BP Tu… - Cell, 2017 - cell.com
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6-adenosine …

[HTML][HTML] Comprehensive comparison of Pacific Biosciences and Oxford Nanopore Technologies and their applications to transcriptome analysis

JL Weirather, M de Cesare, Y Wang, P Piazza… - …, 2017 - ncbi.nlm.nih.gov
Background: Given the demonstrated utility of Third Generation Sequencing [Pacific
Biosciences (PacBio) and Oxford Nanopore Technologies (ONT)] long reads in many …

An improved assembly and annotation of the allohexaploid wheat genome identifies complete families of agronomic genes and provides genomic evidence for …

BJ Clavijo, L Venturini, C Schudoma… - Genome …, 2017 - genome.cshlp.org
Advances in genome sequencing and assembly technologies are generating many high-
quality genome sequences, but assemblies of large, repeat-rich polyploid genomes, such as …

FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome

V Wucher, F Legeai, B Hédan, G Rizk… - Nucleic acids …, 2017 - academic.oup.com
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify …

MYC2 orchestrates a hierarchical transcriptional cascade that regulates jasmonate-mediated plant immunity in tomato

M Du, J Zhao, DTW Tzeng, Y Liu, L Deng, T Yang… - The Plant …, 2017 - academic.oup.com
The hormone jasmonate (JA), which functions in plant immunity, regulates resistance to
pathogen infection and insect attack through triggering genome-wide transcriptional …

Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome

DM Bickhart, BD Rosen, S Koren, BL Sayre… - Nature …, 2017 - nature.com
The decrease in sequencing cost and increased sophistication of assembly algorithms for
short-read platforms has resulted in a sharp increase in the number of species with genome …

Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis

SME Sahraeian, M Mohiyuddin, R Sebra… - Nature …, 2017 - nature.com
Abstract RNA-sequencing (RNA-seq) is an essential technique for transcriptome studies,
hundreds of analysis tools have been developed since it was debuted. Although recent …

Haplotype-resolved sweet potato genome traces back its hexaploidization history

J Yang, MH Moeinzadeh, H Kuhl, J Helmuth, P Xiao… - Nature plants, 2017 - nature.com
Here we present the 15 pseudochromosomes of sweet potato, Ipomoea batatas, the seventh
most important crop in the world and the fourth most significant in China. By using a novel …

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

T Wartewig, Z Kurgyis, S Keppler, K Pechloff… - Nature, 2017 - nature.com
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive
malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells …