The synovium constitutes the envelope of articular joints and is a critical provider of synovial
fluid components and articular cartilage nutrients. Its inflammation is a predominant feature …

Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix
(ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading …

Objectives To compare efficacy and safety of sarilumab monotherapy with adalimumab
monotherapy in patients with active rheumatoid arthritis (RA) who should not continue …

Objectives To assess the efficacy and safety of switching from the infliximab reference
product (RP; Remicade) to its biosimilar CT-P13 (Remsima, Inflectra) or continuing CT-P13 …

Background Sirukumab, a human monoclonal antibody that selectively binds to the
interleukin-6 cytokine with high affinity, is under development for the treatment of rheumatoid …

The introduction of biologic disease–modifying anti-rheumatic drugs (bDMARDs) has
dramatically changed the management of rheumatoid arthritis (RA). However, in a real-life …

Abstract Purpose of the Review In this review, we present the role of regulatory T (Treg) cells
in bone remodelling and bone-related disease such as osteoporosis or inflammatory bone …

Objective To examine the effects of tumor necrosis factor inhibitors on the risk for serious
infections and other influencing factors in a registry. Methods Patients exposed for the first …

Abstract Objective The Italian board for the TAilored BIOlogic therapy (ITABIO) reviewed the
most consistent literature to indicate the best strategy for the second-line biologic choice in …

The programmed cell death 1 (PD-1) receptor plays a major role in regulating T cell
activation. Our aim was to determine how inflammation influences PD-1-mediated T cell …