Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature.
There is no approved pharmacological treatment to effectively slow aneurysm growth or …

The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …

The objective of this study was to investigate whether doxycycline (DOX) given at different
doses and via different administration routes had protective or therapeutic effects on …

The success of endovascular repair of abdominal aortic aneurysms remains limited due to
the development of endoleaks. Sac embolization has been proposed to manage endoleaks …

Aim The water channel aquaporin 1 (AQP 1) promotes endothelial cell migration. It was
hypothesized that AQP 1 promotes neovascularization and growth of atherosclerotic …

Aortic valve disease (AVD) is a common condition with a progressive natural history, and
presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) …

Background Abdominal aortic aneurysm (AAA) is a slowly progressive destructive process of
the main abdominal artery. Experimental studies indicate that fibrates exert beneficial effects …

Aortic aneurysm (AA) is a lethal disease and presents a large challenge for surgeons in the
clinic. Although surgical management remains the major choice of AA, operative mortality …