Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth
J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …
Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin–1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model
Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature.
There is no approved pharmacological treatment to effectively slow aneurysm growth or …
There is no approved pharmacological treatment to effectively slow aneurysm growth or …
Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections
YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …
Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms
M Yu, C Chen, Y Cao, R Qi - European journal of pharmacology, 2017 - Elsevier
The objective of this study was to investigate whether doxycycline (DOX) given at different
doses and via different administration routes had protective or therapeutic effects on …
doses and via different administration routes had protective or therapeutic effects on …
Chitosan-doxycycline hydrogel: An MMP inhibitor/sclerosing embolizing agent as a new approach to endoleak prevention and treatment after endovascular aneurysm …
F Zehtabi, P Ispas-Szabo, D Djerir, L Sivakumaran… - Acta Biomaterialia, 2017 - Elsevier
The success of endovascular repair of abdominal aortic aneurysms remains limited due to
the development of endoleaks. Sac embolization has been proposed to manage endoleaks …
the development of endoleaks. Sac embolization has been proposed to manage endoleaks …
The water channel AQP 1 is expressed in human atherosclerotic vascular lesions and AQP 1 deficiency augments angiotensin II‐induced atherosclerosis in mice
P Wintmo, SH Johansen, PBL Hansen… - Acta …, 2017 - Wiley Online Library
Aim The water channel aquaporin 1 (AQP 1) promotes endothelial cell migration. It was
hypothesized that AQP 1 promotes neovascularization and growth of atherosclerotic …
hypothesized that AQP 1 promotes neovascularization and growth of atherosclerotic …
Inhibition of MAPK‐Erk pathway in vivo attenuates aortic valve disease processes in Emilin1‐deficient mouse model
Aortic valve disease (AVD) is a common condition with a progressive natural history, and
presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) …
presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) …
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial
SE Rowbotham, D Cavaye, R Jaeggi, JS Jenkins… - Trials, 2017 - Springer
Background Abdominal aortic aneurysm (AAA) is a slowly progressive destructive process of
the main abdominal artery. Experimental studies indicate that fibrates exert beneficial effects …
the main abdominal artery. Experimental studies indicate that fibrates exert beneficial effects …
[HTML][HTML] Molecular targets in aortic aneurysm for establishing novel management paradigms
C Hu, K Zhu, J Li, C Wang, L Lai - Journal of Thoracic Disease, 2017 - ncbi.nlm.nih.gov
Aortic aneurysm (AA) is a lethal disease and presents a large challenge for surgeons in the
clinic. Although surgical management remains the major choice of AA, operative mortality …
clinic. Although surgical management remains the major choice of AA, operative mortality …