Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease.
Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is …

Large multicenter clinical trials have led to two recently approved drugs for patients with
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung
disease of unknown etiology. Objectives: The aim of this study was to use whole-exome …

Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality
that is characterized by abnormal scarring of the lung parenchyma. There has been a recent …

Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia (IIP), is characterized by irreversible scarring of the lung parenchyma and …

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …

Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic
Pulmonary Fibrosis (IPF). However, the mechanism of how telomere length is related to …

The gain-of-function mucin 5B (MUC5B) promoter variant, rs35705950, confers the largest
risk, genetic or otherwise, for the development of idiopathic pulmonary fibrosis; however, the …

Pulmonary fibrosis is a relatively rare but devastating disease characterized by the
excessive deposition of extracellular matrix. The increased matrix results in reduced lung …

There has been increasing recognition that genetic factors play important roles in both
sporadic and familial cases of idiopathic pulmonary fibrosis (IPF)(1). Current data indicate …