[HTML][HTML] Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice

LM Gaynor, F Colucci - Frontiers in immunology, 2017 - frontiersin.org
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

[HTML][HTML] High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

A Marçais, M Marotel, S Degouve, A Koenig… - Elife, 2017 - elifesciences.org
NK cell education is the process through which chronic engagement of inhibitory NK cell
receptors by self MHC-I molecules preserves cellular responsiveness. The molecular …

[HTML][HTML] Expression of CD226 is associated to but not required for NK cell education

AK Wagner, N Kadri, J Snäll, P Brodin, S Gilfillan… - Nature …, 2017 - nature.com
Abstract DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating
receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands …

Immunoreceptor tyrosine-based inhibitory motif–dependent functions of an MHC class I-specific NK cell receptor

MD Bern, DL Beckman, T Ebihara… - Proceedings of the …, 2017 - National Acad Sciences
Natural killer (NK) cells express MHC class I (MHC-I)-specific receptors, such as Ly49A, that
inhibit killing of cells expressing self–MHC-I. Self–MHC-I also “licenses” NK cells to become …

Mouse cytomegalovirus encoded immunoevasins and evolution of Ly49 receptors–Sidekicks or enemies?

J Zeleznjak, B Popovic, A Krmpotic, S Jonjic, VJ Lisnic - Immunology letters, 2017 - Elsevier
Cytomegaloviruses (CMVs) have dedicated a large portion of their genome towards immune
evasion targeting many aspects of the host immune system, particularly NK cells. However …

Roles for NK Cells and ILC 1 in Inflammation and Infection

CAJ Vosshenrich, JP Di Santo - Inflammation: From Molecular …, 2017 - Wiley Online Library
Almost four decades ago, human and mouse “natural killer”(NK) cells were discovered
thanks to their capacity to spontaneously lyze tumor cells in vitro. Subsequently, the role for …

Adaptive NK Cell Memory and Nucleosome Interference: Two Tales of the Ly49 Receptor Family

A Wight - 2017 - ruor.uottawa.ca
Ly49 receptors are the canonical natural killer cell class-I major histocompatibility complex
receptors expressed in mice. They have a well-defined role in natural killer cell self/non-self …

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

M Antoine, M Marie, D Sophie, A Koenig… - eLife, 2017 - search.proquest.com
NK cell education is the process through which chronic engagement of inhibitory NK cell
receptors by self MHC-I molecules preserves cellular responsiveness. The molecular …

Natural Killer Cell Education Under Conditions of Perturbed Sensing of MHC: Studies in MHC-I Mosaic and Chimaeric Mice

S Salam - 2017 - search.proquest.com
Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and
transplantation. Their activating and inhibitory receptors sense cell surface ligands on …

[图书][B] The role of NKR-P1: Clr family interactions in murine cytomegalovirus infection

OA Aguilar - 2017 - search.proquest.com
Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and
non-self ligands via paired NK cell receptors (NKR). Here, an MHC-I-independent NK cell …