Covalent inhibitors: an opportunity for rational target selectivity
R Lagoutte, R Patouret, N Winssinger - Current opinion in chemical biology, 2017 - Elsevier
There is a resurging interest in compounds that engage their target through covalent
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …
interactions. Cysteine's thiol is endowed with enhanced reactivity, making it the nucleophile …
Achievements, Challenges, and Opportunities in DNA‐Encoded Library Research: An Academic Point of View
LH Yuen, RM Franzini - ChemBioChem, 2017 - Wiley Online Library
DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that
enable facile screening and identification of bio‐macromolecule binders. The successful …
enable facile screening and identification of bio‐macromolecule binders. The successful …
Discovery of a covalent kinase inhibitor from a DNA-encoded small-molecule library× protein library selection
AI Chan, LM McGregor, T Jain… - Journal of the American …, 2017 - ACS Publications
We previously reported interaction determination using unpurified proteins (IDUP), a method
to selectively amplify DNA sequences encoding ligand: target pairs from a mixture of DNA …
to selectively amplify DNA sequences encoding ligand: target pairs from a mixture of DNA …
Recent advances on the encoding and selection methods of DNA-encoded chemical library
DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for
ligand discovery in chemical biology research and in drug discovery. Encoding and …
ligand discovery in chemical biology research and in drug discovery. Encoding and …
A specific and covalent JNK‐1 ligand selected from an encoded self‐assembling chemical library
G Zimmermann, U Rieder, D Bajic… - … A European Journal, 2017 - Wiley Online Library
We describe the construction of a DNA‐encoded chemical library comprising 148 135
members, generated through the self‐assembly of two sub‐libraries, containing 265 and …
members, generated through the self‐assembly of two sub‐libraries, containing 265 and …
Molecular docking and dynamics simulation study of flavonoids as BET bromodomain inhibitors
U Raj, H Kumar, PK Varadwaj - journal of Biomolecular Structure …, 2017 - Taylor & Francis
Bromodomains (BRDs) are the epigenetic proteins responsible for transcriptional regulation
through its interaction with methylated or acetylated histone residues. The lysine residues of …
through its interaction with methylated or acetylated histone residues. The lysine residues of …
Universal and quantitative method to evaluate inhibitor potency for cysteinome proteins using a nonspecific activity-based protein profiling probe
T Sameshima, Y Tanaka, I Miyahisa - Biochemistry, 2017 - ACS Publications
Recently, there have been a limited number of new, validated targets for small-molecule
drug discovery in the pharmaceutical industry. Although there are approximately 30 000 …
drug discovery in the pharmaceutical industry. Although there are approximately 30 000 …