Neuroinflammation as fuel for axonal regeneration in the injured vertebrate central nervous system

I Bollaerts, J Van Houcke, L Andries… - Mediators of …, 2017 - Wiley Online Library
Damage to the central nervous system (CNS) is one of the leading causes of morbidity and
mortality in elderly, as repair after lesions or neurodegenerative disease usually fails …

Evolutionary aspects of macrophages polarization

ES Edholm, KH Rhoo, J Robert - Macrophages: Origin, Functions and …, 2017 - Springer
Macrophages constitute a heterogeneous population of myeloid cells that are essential for
maintaining homeostasis and as a first line of innate responders controlling and organizing …

Macrophages are necessary for epimorphic regeneration in African spiny mice

J Simkin, TR Gawriluk, JC Gensel, AW Seifert - elife, 2017 - elifesciences.org
How the immune system affects tissue regeneration is not well understood. In this study, we
used an emerging mammalian model of epimorphic regeneration, the African spiny mouse …

TNF signaling and macrophages govern fin regeneration in zebrafish larvae

M Nguyen-Chi, B Laplace-Builhé, J Travnickova… - Cell death & …, 2017 - nature.com
Macrophages are essential for appendage regeneration after amputation in regenerative
species. The molecular mechanisms through which macrophages orchestrate blastema …

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

DT White, S Sengupta, MT Saxena… - Proceedings of the …, 2017 - National Acad Sciences
Müller glia (MG) function as inducible retinal stem cells in zebrafish, completely repairing the
eye after damage. The innate immune system has recently been shown to promote tissue …

Macrophage-dependent cytoplasmic transfer during melanoma invasion in vivo

M Roh-Johnson, AN Shah, JA Stonick, KR Poudel… - Developmental cell, 2017 - cell.com
Interactions between tumor cells and tumor-associated macrophages play critical roles in
the initiation of tumor cell motility. To capture the cellular interactions of the tumor …

Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

C Gerri, R Marín-Juez, M Marass, A Marks… - Nature …, 2017 - nature.com
Macrophages are known to interact with endothelial cells during developmental and
pathological angiogenesis but the molecular mechanisms modulating these interactions …

Trends in tissue repair and regeneration

B Galliot, M Crescenzi, A Jacinto… - Development, 2017 - journals.biologists.com
The 6th EMBO conference on the Molecular and Cellular Basis of Regeneration and Tissue
Repair took place in Paestum (Italy) on the 17th-21st September, 2016. The 160 scientists …

Modeling infectious diseases in the context of a developing immune system

S Masud, V Torraca, AH Meijer - Current topics in developmental biology, 2017 - Elsevier
Zebrafish has been used for over a decade to study the mechanisms of a wide variety of
inflammatory disorders and infections, with models ranging from bacterial, viral, to fungal …

CXCR3. 1 and CXCR3. 2 differentially contribute to macrophage polarization in teleost fish

XJ Lu, Q Chen, YJ Rong, F Chen… - The Journal of …, 2017 - journals.aai.org
The study of multiple copies of chemokine receptor genes in various teleosts has long
appealed to investigators seeking to understand the evolution of the immune system. The …