Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease

AW McHill, KP Wright Jr - Obesity reviews, 2017 - Wiley Online Library
Weight gain, obesity and diabetes have reached alarming levels in the developed world.
Traditional risk factors such as over‐eating, poor nutritional choices and lack of exercise …

Inflammaging, metabolic syndrome and melatonin: a call for treatment studies

DP Cardinali, R Hardeland - Neuroendocrinology, 2017 - karger.com
The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease,
including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia …

Melatonin and the pathologies of weakened or dysregulated circadian oscillators

R Hardeland - Journal of pineal research, 2017 - Wiley Online Library
Dynamic aspects of melatonin's actions merit increasing future attention. This concerns
particularly entirely different effects in senescent, weakened oscillators and in dysregulated …

Melatonin supplementation lowers oxidative stress and regulates adipokines in obese patients on a calorie‐restricted diet

K Szewczyk-Golec, P Rajewski… - Oxidative medicine …, 2017 - Wiley Online Library
Obesity is one of the major global health problems. Melatonin deficiency has been
demonstrated to correlate with obesity. The aim of the study was to estimate the effect of …

Chronomedicine and type 2 diabetes: shining some light on melatonin

AC Forrestel, SU Miedlich, M Yurcheshen, SD Wittlin… - Diabetologia, 2017 - Springer
In mammals, the circadian timing system drives rhythms of physiology and behaviour,
including the daily rhythms of feeding and activity. The timing system coordinates temporal …

Melatonin, mitochondria, and the metabolic syndrome

DP Cardinali, DE Vigo - Cellular and molecular life sciences, 2017 - Springer
A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose
intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as …

A single night light exposure acutely alters hormonal and metabolic responses in healthy participants

MS Albreiki, B Middleton… - Endocrine connections, 2017 - ec.bioscientifica.com
The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1
and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic …

Diagnosis and treatment of non-24-h sleep–wake disorder in the blind

JS Emens, CI Eastman - Drugs, 2017 - Springer
Abstract Non-24-h sleep–wake disorder (non-24) is a circadian rhythm disorder occurring in
55–70% of totally blind individuals (those lacking conscious light perception) in which the 24 …

Exposure to night-time traffic noise, melatonin-regulating gene variants and change in glycemia in adults

IC Eze, M Imboden, M Foraster, E Schaffner… - International journal of …, 2017 - mdpi.com
Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We
hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis …

Associations between nocturnal urinary 6-sulfatoxymelatonin, obstructive sleep apnea severity and glycemic control in type 2 diabetes

S Reutrakul, N Siwasaranond… - Chronobiology …, 2017 - Taylor & Francis
Reduced nocturnal secretion of melatonin, a pineal hormone under circadian control, and
obstructive sleep apnea have been both identified as risk factors for the development of type …