Each year over 16 million older Americans undergo general anesthesia for surgery, and up
to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and …

Recent studies have investigated local oscillations, long-range connectivity, and global
network patterns to identify neural changes associated with anesthetic-induced …

• In the early 1990s, Steriade contributed to our understanding of the neurophysiology of
sleep and general anaesthesia in animals, including descriptions of three distinct …

In the current literature on scientific explanation unification became unfashionable in favour
of causal approaches. We want to bring unification back into the picture. In this paper we …

There is as yet no generalised theory of anaesthesia. This lack of understanding of the
mechanisms underpinning general anaesthesia is partly due to a lack of convergence of the …

The main goals of neurosurgical anesthesia are to provide the patient with an adequate
anesthetic that provides a stable hemodynamics, reduces cerebral metabolism, avoids …

OBJECTIVES: The default mode resting state network (DMRSN) constitutes a circuit which is
active in conditions when the subject is at rest. We tested the hypothesis that its function will …

General anesthesia consists of key separable and independent neurobiological end points.
Each of these involves distinct but possibly overlapping neuroanatomical and molecular …

This topical quote was continued as “in the end that's all there is.” In a sense this highlights
how memory makes us uniquely human. As the human mind is the most complex creation in …

The electroencephalogram (EEG) is a measure of brain-activity commonly used during
clinical general anaesthesia. During surgery, and during the process of returning to …