Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Suicidal NETosis differs from other mechanisms of cell death by the release of a lattice,
composed of DNA associated with proteins citrullinated by protein-arginine deiminase 4 …

Purpose To investigate the levels of neutrophil elastase (NE), matrix metalloproteinases
(MMPs), and myeloperoxidase (MPO) in tear washes of patients with ocular graft-vs-host …

Purpose To evaluate whether NETosis is involved in cytokine-induced ocular inflammation
and to track neutrophil extracellular traps (NET) complexes in patients with proliferative …

Abstract Introduction Neutrophil extracellular traps (NETs) are formed by activated
neutrophils during the process of NETosis in which the nuclear material is released into …

Glucocorticoid eye drops are one of the most widely used medications in ophthalmology.
However, little is known about the effects of glucocorticoids on corneal epithelial cells that …

High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene
expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) …

Abstract Dry Eye Disease (DED) is “a multifactorial disease of the tears and ocular surface
that results in symptoms of discomfort, visual disturbance, and tear-film instability with …

Abstract Polymorphonuclear (neutrophil) granulocytes (PMNs) are an essential part of the
innate immune responses and key instigators and effectors of the underlying pathological …

Résumé La NETose suicidaire diffère des autres morts cellulaires par l'expulsion d'ADN
nucléaire mélangé à des protéines préalablement citrullinées par l'arginine déiminase 4 des …