Importance Primary tumor location is emerging as an important prognostic factor owing to
distinct biological features. However, the side of origin of colon cancer (CC) still does not …

Although clinical management of colon cancer generally has not accounted for the primary
tumor site, left-sided and right-sided colon cancers harbor different clinical and biologic …

Background Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high
(MSI-H) colorectal cancer has a poor prognosis after treatment with conventional …

Purpose Molecular diagnostic testing has become an integral part of the evaluation of
patients with metastatic colorectal cancer (CRC). Expanded mutational testing, such as next …

The MAPK cascade plays a crucial role in tumor cell proliferation and survival. Accumulating
evidence suggests that mutations in the BRAF oncogene are not only associated with poor …

2.1 Geltungsbereich und Zweck 2.1. 1. Zielsetzung und Fragestellung Das Kolorektale
Karzinom (KRK) ist mit etwa 64 000 Neuerkrankungen und ca. 26 000 Todesfällen pro Jahr …

Background To improve strategies for the treatment ofBRAF-mutant advanced colorectal
cancer (aCRC) patients, we examined individual data from patients treated with …

Since the MOSAIC study, oxaliplatin-based adjuvant chemotherapy has been the standard
treatment of stage III colon cancer. Combination therapy with fluoropyrimidines and …

Background The purpose of the study was to evaluate whether the mutational status of
Kirsten rat sarcoma viral oncogene homolog (KRAS) or b-viral oncogene homolog B1 …

Over the past decade there have been significant advances in the molecular
characterization of colorectal cancer (CRC) that are driving treatment decisions. Expanded …