Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy

PR Williamson, JN Jarvis, AA Panackal… - Nature Reviews …, 2017 - nature.com
HIV-associated cryptococcal meningitis is by far the most common cause of adult meningitis
in many areas of the world that have high HIV seroprevalence. In most areas in Sub …

Evolution of bacterial virulence

M Diard, WD Hardt - FEMS microbiology reviews, 2017 - academic.oup.com
Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …

Host–microbe interactions: Malassezia and human skin

EA Grice, TL Dawson - Current opinion in microbiology, 2017 - Elsevier
Highlights•Malassezia are dominant eukaryotic microflora of human and animal
skin.•Malassezia interact with the mammalian host in both direct (toxic/irritant) and indirect …

Immunotherapeutic approaches to treatment of fungal diseases

D Armstrong-James, GD Brown, MG Netea… - The Lancet Infectious …, 2017 - thelancet.com
Fungal infections cause morbidity worldwide and are associated with an unacceptably high
mortality despite the availability of antifungal drugs. The incidence of mycoses is rising …

[HTML][HTML] Colonizing opportunistic pathogens (COPs): The beasts in all of us

LB Price, BA Hungate, BJ Koch, GS Davis… - PLoS …, 2017 - journals.plos.org
Colonizing opportunistic pathogens (COPs) are microbes that asymptomatically colonize the
human body and, when the conditions are right, can cause infections. Their ability to persist …

[HTML][HTML] Fungal interactions with the human host: exploring the spectrum of symbiosis

RA Hall, MC Noverr - Current opinion in microbiology, 2017 - Elsevier
Highlights•A model of symbiosis as a function of host damage is proposed.•Transition from
commensalism to parasitism is dependent on host, environmental and fungal …

CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis

LM Neal, E Xing, J Xu, JL Kolbe, JJ Osterholzer… - MBio, 2017 - Am Soc Microbiol
Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …

[HTML][HTML] Central role of IL-23 and IL-17 producing eosinophils as immunomodulatory effector cells in acute pulmonary aspergillosis and allergic asthma

ES Guerra, CK Lee, CA Specht, B Yadav… - PLoS …, 2017 - journals.plos.org
Aspergillus fumigatus causes invasive pulmonary disease in immunocompromised hosts
and allergic asthma in atopic individuals. We studied the contribution of lung eosinophils to …

[HTML][HTML] Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

SR Beattie, KMK Mark, A Thammahong… - PLoS …, 2017 - journals.plos.org
Aspergillus fumigatus is responsible for a disproportionate number of invasive mycosis
cases relative to other common filamentous fungi. While many fungal factors critical for …

Transgenerational Diapause as an Avoidance Strategy against Bacterial Pathogens in Caenorhabditis elegans

MF Palominos, L Verdugo, C Gabaldon, B Pollak… - MBio, 2017 - Am Soc Microbiol
The dynamic response of organisms exposed to environmental pathogens determines their
survival or demise, and the outcome of this interaction depends on the host's susceptibility …