Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Neurotrophic factors comprise essential secreted proteins that have several functions in
neural and non-neural tissues, mediating the development, survival and maintenance of …

Neurotrophic factors comprise a broad family of biomolecules–most of which are peptides or
small proteins–that support the growth, survival and differentiation of both developing and …

Neuroplasticity is not only shaped by learning and memory but is also a mediator of
responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it …

Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …

Neuronal plastic rearrangements during the development and functioning of neurons are
largely regulated by trophic factors, including nerve growth factor (NGF). NGF is also …

Although p75 neurotrophin receptor (p75 NTR) was the founding member of the tumor
necrosis factor (TNF) receptor superfamily (TNFRSF), it is an atypical TNFRSF protein. p75 …

Ubiquitination is a reversible post-translational modification involved in a plethora of
different physiological functions. Among the substrates that are ubiquitinated, neurotrophin …

Producing the neuronal diversity required to adequately discriminate all elements of
somatosensation is a complex task during organogenesis. The mechanisms guiding this …

Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by a
progressive decline in cognition and memory, leading to significant impairment in daily …