Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its
risk is higher among women, racial and ethnic minorities, and individuals with a family …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …

Autoimmunity and chronic inflammation recognize numerous shared factors and, as a result,
the resulting diseases frequently coexist in the same patients or respond to the same …

Among the epigenetic changes, histone acetylation has been recognized as a fundamental
process that strongly affects gene expression regulation. Disrupt of this phenomenon has …

Abstract Purpose of Review Systemic lupus erythematosus is a severe autoimmune/
inflammatory condition of unknown pathophysiology. Though genetic predisposition is …

Epigenetic modifications can stably alter gene expression and have been shown to be
important in the maintenance of cell type-specific functions as well as in cell differentiation …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease facilitated by
aberrant immune responses directed against cells and tissues, resulting in inflammation and …

Associations between epigenetic alterations and disease status have been identified for
many diseases. However, there is no strong evidence that epigenetic alterations are directly …

Factors are reviewed that contribute to the contemporary view of a disproportionate
prevalence and incidence of SLE in females. Recent studies on the epidemiology of SLE …

Monozygotic twins share an identical DNA sequence but are not truly “identical”. In fact,
when it comes to health and disease, they may often display some level of phenotypic …