Keep them breathing: Cystic fibrosis pathophysiology, diagnosis, and treatment

SD Brown, R White, P Tobin - Jaapa, 2017 - journals.lww.com
Cystic fibrosis (CF) affects more than 30,000 people in the United States and 80,000 people
worldwide. This life-threatening genetic disorder causes a buildup of thick, viscous mucus …

Interactions between Neutrophils and Pseudomonas aeruginosa in Cystic Fibrosis

B Rada - Pathogens, 2017 - mdpi.com
Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely
caused by lung complications due to the triad of impaired mucociliary clearance, microbial …

[HTML][HTML] Brazilian guidelines for the diagnosis and treatment of cystic fibrosis

RA Athanazio, LVRF Silva, AA Vergara… - Jornal Brasileiro de …, 2017 - SciELO Brasil
Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction
of the CFTR gene. It is a multisystem disease that most often affects White individuals. In …

Diretrizes brasileiras de diagnóstico e tratamento da fibrose cística

RA Athanazio, LVRF Silva, AA Vergara… - Jornal brasileiro de …, 2017 - SciELO Brasil
RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva
caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que …

Strategies for the etiological therapy of cystic fibrosis

L Maiuri, V Raia, G Kroemer - Cell Death & Differentiation, 2017 - nature.com
Etiological therapies aim at repairing the underlying cause of cystic fibrosis (CF), which is
the functional defect of the cystic fibrosis transmembrane conductance regulator (CFTR) …

Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo

LH Peng, W Wei, YH Shan, YS Chong… - Drug Development …, 2017 - Taylor & Francis
This study aims to investigate the solid lipid nanoparticle (SLN) as a novel vehicle for the
sustained release and transdermal delivery of piroxicam, as well as to determine the anti …

Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 pathways

X Dong, Y Jia, B Jiang, J Jiang, J Shen, Y Jin, Y Guan… - Toxicology, 2017 - Elsevier
Bleomycin (BLM) has potent tumor cell-killing properties that have given it an important
place in cancer chemotherapy, but pulmonary toxicity is its major adverse effect. Soluble …

Is the perceived placebo effect comparable between adults and children? A meta-regression analysis

P Janiaud, C Cornu, A Lajoinie, A Djemli… - Pediatric …, 2017 - nature.com
Background: A potential larger perceived placebo effect in children compared with adults
could influence the detection of the treatment effect and the extrapolation of the treatment …

Digitoxin for airway inflammation in cystic fibrosis: preliminary assessment of safety, pharmacokinetics, and dose finding

PL Zeitlin, M Diener-West, KA Callahan… - Annals of the …, 2017 - atsjournals.org
Rationale: Cystic fibrosis (CF) lung disease progresses by a combination of airway
inflammation, bacterial colonization, and infection. Airway inflammation is predominantly …

[图书][B] Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

VK Sidhaye, M Koval - 2017 - books.google.com
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop
resource capturing developments in lung epithelial biology related to basic physiology …