Since the introduction of general anaesthetics into clinical practice, researchers have been
mystified as to how these chemically disparate drugs act to produce their dramatic effects on …

General anesthetics revolutionized medicine by allowing surgeons to perform more complex
and much longer procedures. This widely used class of drugs is essential to patient care, yet …

General anesthetics have revolutionized medicine by facilitating invasive procedures, and
have thus become essential drugs. However, detailed understanding of their molecular …

Sepsis continues to result in high morbidity and mortality. General anesthesia is often
administered to septic patients, but the impacts of general anesthesia on host defense are …

Although general anesthetics are routinely administered to surgical patients to induce loss of
consciousness, the mechanisms underlying anesthetic-induced unconsciousness are not …

Phase-rectified signal averaging (PRSA) has been known to be a useful method to detect
periodicities in non-stationary biological signals. Determination of quasi-periodicities in …

General anesthetics exert their effects on the central nervous system by acting on ion
channels, most notably pentameric ligand-gated ion channels. Although numerous studies …

Organophosphate chemical threat agents (OP-CTA) exert toxic effects through cholinergic
over-activation. However, after the initial cholinergic phase, the pathophysiology shifts to a …

The anesthetic agents used to produce general anesthesia and the physiological
management have an impact on the ability of intraoperative neurophysiological monitoring …

Propofol (PFL, 1-hydroxyl-2, 6-diisopropylbenzene) is currently used widely as one of the
most well-known intravenous anesthetics to relieve surgical suffering, but its mechanism of …