Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the
presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption …

hydroxytryptamine type 3 (5-HT 3) receptor antagonists are used in the prevention of
chemotherapy-induced, radiation-induced and postoperative nausea and vomiting. CYP2D6 …

BACKGROUND The use of opioids to alleviate pain is complicated by the risk of severe
adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) …

Cytochrome P450 (CYP) enzymes are commonly involved in drug metabolism, and genetic
variation in the genes encoding CYPs are associated with variable drug response. While …

Aims Clonidine is used for sedation in the paediatric intensive care unit. Extracorporeal
membrane oxygenation (ECMO) provides temporary support if respiratory and cardiac …

Purpose In view of pediatric drug development, juvenile animal studies are gaining
importance. However, data on drug metabolizing capacities of juvenile animals are scarce …

A large number of chemicals are routinely detected in aquatic environments, and these
chemicals may adversely affect aquatic organisms. Accurate risk assessment requires …

The developmental protein expression pattern of the closely related hepatic uptake
transporters, OATP1B1 and OATP1B3, was examined in human liver tissue samples …

Medication use during pregnancy is very common, but can potentially harm the unborn child.
Many studies have evaluated the safety of certain medications, but data are still lacking. The …

Paving ways for personalizing drug therapy during pregnancy University of Groningen Paving
ways for personalizing drug therapy during pregnancy Daud, Nur IMPORTANT NOTE: You are …