The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …

Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein
particles, known as Lewy bodies. The second most common neurodegenerative disorder …

The prevailing view is that striatal parvalbumin (PV)-positive interneurons primarily function
to downregulate medium spiny projection neuron (MSN) activity via monosynaptic inhibitory …

Parkinson's disease (PD) patients experience loss of normal motor function (hypokinesia),
but can develop uncontrollable movements known as dyskinesia upon treatment with L …

Converting resident glia into functional and subtype-specific neurons in vivo by delivering
reprogramming genes directly to the brain provides a step forward toward the possibility of …

The motor symptoms of Parkinson's disease (PD) are linked to abnormally correlated and
coherent activity in the cortex and subthalamic nucleus (STN). However, in parkinsonian …

Classical schemes of basal ganglia organization posit that parkinsonian movement
difficulties presenting after striatal dopamine depletion stem from the disproportionate firing …

Parkinson's disease (PD) is a movement disorder caused by the loss of dopaminergic
innervation, particularly to the striatum. PD patients often exhibit sensory impairments, yet …

The basal ganglia (BG) are the major subcortical nuclei in the brain. Disorders implicating
the BG are characterized by diverse symptoms, but it remains unclear what these symptoms …

Two distinct motor areas, the primary and secondary motor cortices (M1 and M2), play
crucial roles in voluntary movement in rodents. The aim of this study was to characterize the …