Pediatric pulmonary vascular disease (PVD) and pulmonary hypertension (PH) represent
phenotypically and pathophysiologically diverse disease categories, contributing substantial …

Tissue matrix remodeling and fibrosis leading to loss of pulmonary arterial and right
ventricular compliance are important features of both experimental and clinical pulmonary …

Prematurity complicates 12% of births, and young adults with a history of prematurity are at
risk to develop right ventricular (RV) hypertrophy and impairment. The long-term risk for …

Background Doppler echocardiography is ideally suited for assessment of diastolic function,
being widely available, non-invasive, and less expensive than other techniques. However …

Pulmonary hypertension (PH) results in significant morbidity and mortality. Chronic PH
animal models may advance the study of PH's mechanisms, evolution, and therapy. In this …

Pulmonary arterial hypertension (PAH) is characterised by an elevation in afterload imposed
on the right ventricle (RV), leading to hypertrophy and failure. The autonomic nervous …

Pulmonary arterial hypertension (PAH) is caused by extensive pulmonary vascular
remodeling that increases right ventricular (RV) afterload and leads to RV failure. PAH …

17β-estradiol (E2) exerts complex and context-dependent effects in pulmonary
hypertension. In hypoxia-induced pulmonary hypertension (HPH), E2 attenuates lung …

Although the incidence of pulmonary hypertension is higher in females, the severity and
prognosis of pulmonary vascular disease in both neonates and adults have been shown to …

Males and females are biologically distinct, and certain pathological conditions affect both
sexes differently. Obvious sex difference exists in pulmonary arterial hypertension (PAH) …