Gout is a picturesque presentation of uric acid disturbance. It is the most well understood
and described type of arthritis. Its epidemiology is studied. New insights into the …

Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …

Background Increasing evidence supports the association between hyperuricemia and
incident chronic kidney disease (CKD); however, there are conflicting data regarding the …

Objectives Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added
to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised …

Objective To investigate the efficacy and safety of lesinurad in combination with febuxostat in
a 12‐month phase III trial in patients with tophaceous gout. Methods Patients with serum …

Objectives To determine the efficacy and safety of allopurinol dose escalation using a treat-
to-target serum urate (SU) approach. Methods A randomised, controlled, parallel-group …

Objectives Weight loss is commonly recommended for gout, but the magnitude of the effect
has not been evaluated in a systematic review. The aim of this systematic review was to …

Objective To investigate the efficacy and safety of lesinurad, a selective uric acid
reabsorption inhibitor, in a 6 month, phase 3 clinical trial and extension study. Methods …

Objective Gout, the most common inflammatory arthritis, is associated with premature
mortality. Whether this mortality gap has improved over time, as observed in rheumatoid …