Body weight stability requires homeostatic regulation to balance energy intake and energy
expenditure. Research on this system and how it is affected by obesity has largely focused …

Obesity is considered one of the greatest risk to human health and is associated with several
factors including genetic components, diet, and physical inactivity. Recently, the relationship …

Endoplasmic reticulum (ER) is a subcellular organelle involved in protein folding and
processing. ER stress constitutes a cellular process characterized by accumulation of …

Although the brain is composed of numerous cell types, neurons have received the vast
majority of attention in the attempt to understand how this organ functions. Neurons are …

Astrocytes exert a wide variety of functions with paramount importance in brain physiology.
After injury or infection, astrocytes become reactive and they respond by producing a variety …

The understanding of the mechanisms whereby energy balance is regulated is essential to
the unraveling of the pathophysiology of obesity. In the last three decades, focus was put on …

Accumulated evidence indicates that obesity‐induced type 2 diabetes (T2D) is associated
with enhanced sympathetic activation. The present study was conducted to investigate the …

Our understanding of adipose tissue as an endocrine organ has been transformed over the
last twenty years. During this time a number of adipocyte-derived factors or adipokines have …

The present study investigated whether male offspring (F2 generation) from female rats (F1
generation) whose mothers (F0 generation) were food restricted during gestation inherit a …

Hypothalamus plays the central role in regulating energy homeostasis. To understand the
hypothalamic neurocircuit in responding to leptin, Manganese-Enhanced MRI (MEMRI) was …