Oxidative stress, protein modification and Alzheimer disease

A Tramutola, C Lanzillotta, M Perluigi… - Brain research bulletin, 2017 - Elsevier
Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the elderly
population with complex etiology. Many hypotheses have been proposed to explain different …

[HTML][HTML] Neurodegeneration in diabetic retinopathy: potential for novel therapies

AJ Barber, B Baccouche - Vision research, 2017 - Elsevier
The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis

A Della Giustina, MP Goldim, LG Danielski… - Neurochemistry …, 2017 - Elsevier
Sepsis is a complication of an infection which imbalance the normal regulation of several
organ systems, including the central nervous system (CNS). Evidence points towards …

L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation

J Chen, W Yin, Y Tu, S Wang, X Yang, Q Chen… - European journal of …, 2017 - Elsevier
Microglia and astrocytes are largely responsible for inflammatory injury in the brain of
Alzheimer's disease (AD). Increasing evidence has indicated that Rho kinase (ROCK) plays …

The potential protective effect of α-lipoic acid against nanocopper particle–induced hepatotoxicity in male rats

AA Khalaf, AR Zaki, MK Galal… - Human & …, 2017 - journals.sagepub.com
The present research task is aimed to evaluate the role of exogenous α-lipoic acid
(ALA)(100 mg/kg body weight) as hepatoprotective and potent antioxidant in amelioration of …

Bioresponsive Chimaeric Nanopolymersomes Enable Targeted and Efficacious Protein Therapy for Human Lung Cancers in Vivo

W Yang, Y Xia, Y Zou, F Meng, J Zhang… - Chemistry of …, 2017 - ACS Publications
Rapidly evolving protein technology has generated hundreds of therapeutic proteins that are
promising for treating various human diseases. The clinical use of protein drugs remains …

Efficient delivery of paclitaxel into ASGPR over-expressed cancer cells using reversibly stabilized multifunctional pullulan nanoparticles

L Huang, Y Wang, X Ling, B Chaurasiya, C Yang… - Carbohydrate …, 2017 - Elsevier
Core-crosslinked pullulan nanoparticles (Pull-LA-CLNPs) were synthesized by the reduction-
sensitive strategy for paclitaxel (PTX) delivery. Pull-LA-CLNPs showed high stability against …

Polymeric drug delivery micelle-like nanocarriers for pulmonary administration of beclomethasone dipropionate

D Triolo, EF Craparo, B Porsio, C Fiorica… - Colloids and Surfaces B …, 2017 - Elsevier
In this paper, the potential of novel polymeric micelles as drug delivery systems for
Beclomethasone Dipropionate (BDP) administration into the lung is investigated. These …

Lipoic acid functionalized SiO2@ Ag nanoparticles. Synthesis, characterization and evaluation of biological activity

M Tudose, DC Culita, AM Musuc, S Somacescu… - Materials Science and …, 2017 - Elsevier
A novel nanocomposite was obtained through the covalent immobilization of lipoic acid on
the surface of silver nanoparticles-decorated silica nanoparticles (SiO 2@ Ag). The hybrid …

[HTML][HTML] A novel DSC approach for evaluating protectant drugs efficacy against dementia

S Abarova, R Koynova, L Tancheva… - Biochimica et Biophysica …, 2017 - Elsevier
Differential scanning calorimetry was applied to evaluate the efficacy of preventive
treatments with biologically active compounds of plant origin against neurodegenerative …