Post translational modifications (PTMs) are involved in variety of cellular activities and
phosphorylation is one of the most extensively studied PTM, which regulates a number of …

Highlights•Phosphorylation is a rapid and transient switch for PTI.•PTM links metabolic
pathways important for defense.•PTM of TSB1 counters pathogen virulence strategies.•PTM …

Lipids are essential cellular components and energy sources of living organisms, and
altered lipid composition is increasingly recognized as a signature of cancer. We performed …

Mitochondria are one of most characterized metabolic hubs of the cell. Here, crucial
biochemical reactions occur and most of the cellular adenosine triphosphate (ATP) is …

Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is
key to understanding the role of protein phosphorylation. Here we report an efficient method …

Abstract HER2/ERBB2–overexpressing breast cancers targeted effectively by the small-
molecule kinase inhibitor lapatinib frequently acquire resistance to this drug. In this study …

Significance:“Nitroproteomic” is under active development, as 3-nitrotyrosine in proteins
constitutes a footprint left by the reactions of nitric oxide-derived oxidants that are usually …

The application of global “-omics” technologies to exercise has introduced new opportunities
to map the complexity and interconnectedness of biological networks underlying the tissue …

Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to
produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and …

Activation of the RAS-RAF-MEK-ERK signaling pathway is implicated in driving the initiation
and progression of multiple cancers. Several inhibitors targeting the RAS-MAPK pathway …