Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Gasotransmitter delivery via self-assembling peptides: treating diseases with natural signaling gases

Y Qian, JB Matson - Advanced Drug Delivery Reviews, 2017 - Elsevier
Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S) are powerful
signaling molecules that play a variety of roles in mammalian biology. Collectively called …

Detection of plasma biomarkers using immunomagnetic reduction: a promising method for the early diagnosis of Alzheimer's disease

SY Yang, MJ Chiu, TF Chen, HE Horng - Neurology and therapy, 2017 - Springer
Alzheimer's disease (AD) is the most common form of dementia. The development of assay
technologies able to diagnose early-stage AD is important. Blood tests to detect biomarkers …

Tocotrienol-rich fraction modulates amyloid pathology and improves cognitive function in AβPP/PS1 mice

NF Ibrahim, D Yanagisawa, LW Durani… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is the most common cause of dementia. The cardinal
neuropathological characteristic of AD is the accumulation of amyloid-β (Aβ) into …

Identification of key interactions in the initial self-assembly of amylin in a membrane environment

M Christensen, KK Skeby, B Schiøtt - Biochemistry, 2017 - ACS Publications
Islet amyloid polypeptide, also known as amylin, forms aggregates that reduce the amount of
insulin-producing cells in patients with type II diabetes mellitus. Much remains unknown …

Inhibitory mechanism of epigallocatechin gallate on fibrillation and aggregation of amidated human islet amyloid polypeptide

ZX Xu, GL Ma, Q Zhang, CH Chen, YM He… - …, 2017 - Wiley Online Library
The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) is associated with
development of type II diabetes mellitus (T2DM).(−)‐Epigallocatechin gallate (EGCG) can …

Inhibition of the aggregation and toxicity of the minimal amyloidogenic fragment of tau by its pro‐substituted analogues

M Chemerovski‐Glikman… - … A European Journal, 2017 - Wiley Online Library
Inhibiting the toxic aggregation of amyloid‐β and the tau protein, the key pathological agents
involved in Alzheimer's, is a leading approach in modulating disease progression. Using an …

Nanostructured antigen-responsive hydrogels based on peptides for leishmaniasis detection

SF Souza, SK Jr, ER Silva, WA Alves - Journal of the Brazilian …, 2017 - SciELO Brasil
Hydrogels based on peptide nanostructures are biological entities that can be applied in a
wide range of applications, such as scaffolds for tissue engineering, drug delivery, and …

Modulation of prion polymerization and toxicity by rationally designed peptidomimetics

A Srivastava, S Sharma, S Sadanandan… - Biochemical …, 2017 - portlandpress.com
Misfolding and aggregation of cellular prion protein is associated with a large array of
neurological disorders commonly called the transmissible spongiform encephalopathies …

Interactions of aromatic residues in amyloids: a survey of protein data bank crystallographic data

IM Stanković, DM Bozinovski, EN Brothers… - Crystal Growth & …, 2017 - ACS Publications
Aromatic–aromatic interactions have long been considered important in the self-assembly of
amyloids. In spite of their importance, aromatic amino acids are not detected in every …