Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?

IK Delattre, FS Taccone, F Jacobs, M Hites… - Expert review of anti …, 2017 - Taylor & Francis
Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study

L Ehmann, M Zoller, IK Minichmayr, C Scharf, B Maier… - Critical care, 2017 - Springer
Background Severe bacterial infections remain a major challenge in intensive care units
because of their high prevalence and mortality. Adequate antibiotic exposure has been …

Population pharmacokinetics and pharmacodynamics of meropenem in nonobese, obese, and morbidly obese patients

EK Chung, SC Cheatham, MR Fleming… - The Journal of …, 2017 - Wiley Online Library
The study objective was to evaluate meropenem population pharmacokinetics and
pharmacodynamics in nonobese, obese, and morbidly obese patients. Forty adult patients …

[PDF][PDF] Recomendaciones SOCHIMI para el Manejo Inicial de la Sepsis

C Romero, C Luengo, T Regueira… - Revista Chilena de …, 2017 - medicina-intensiva.cl
La sepsis y el shock séptico constituyen una emergencia sanitaria, alrededor del mundo
cobran la vida de miles de personas cada día, situándolas como la principal causa de …

Effects of clinically meaningful concentrations of antipseudomonal β-lactams on time to detection and organism growth in blood culture bottles

M Grupper, DP Nicolau, J Aslanzadeh… - Journal of Clinical …, 2017 - Am Soc Microbiol
The effectiveness of antimicrobial binding resins present in blood culture (BC) bottles in
removing meropenem, ceftolozane-tazobactam, and ceftazidime-avibactam is unknown. We …

Нозокомиальная пневмония, связанная с искусственной вентиляцией легких: антибактериальная терапия короткими курсами

ВБ Белобородов, ВА Синикин - Consilium medicum, 2017 - cyberleninka.ru
Нозокомиальная пневмония, связанная с искусственной вентиляцией легких (НПивл),
является наиболее частым видом инфекции у пациентов в критических состояниях …

Nosocomial pneumonia associated with artificial ventilation of the lungs: antibacterial therapy with short courses

VB Beloborodov, VA Sinikin - Consilium medicum, 2017 - journals.eco-vector.com
Abstract Ventilator-associated pneumonia (VAP), is the most common infection in critically ill
patients, significantly increases the risk of death, often caused by resistant flora …

Ventilator-associated pneumonia: antibacterial therapy with short courses

VB Beloborodov, VA Sinikin - Consilium Medicum, 2017 - journals.eco-vector.com
Ventilator-associated pneumonia is one of the current problems of intensive care due to high
prevalence, insufficient treatment effectiveness, additional costs associated with lengthening …