Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

The history of fecal microbiota transplantation (FMT) dates back even to ancient China.
Recently, scientific studies have been looking into FMT as a promising treatment of various …

Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …

Here, we review three sets of key proteins and their corresponding downstream pathways
that have been linked to extending lifespan and promoting health span in a wide range of …

The causal relationships between insulin levels, insulin resistance, and longevity are not
fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling …

Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular
nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR …

Interventions that extend lifespan in mice can show substantial sexual dimorphism. Here, we
show that male‐specific lifespan extension with two pharmacological treatments, acarbose …

Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with
longevity and metabolic fitness. The mechanisms underlying these benefits are poorly …

Males and females in many species differ in how they age and how long they live. These
differences have motivated much research, concerning both their evolution and the …

The interrelationships of growth hormone (GH) actions and aging are complex and
incompletely understood. The very pronounced age-related decline in GH secretion together …