Template‐Mediated Stabilization of a DNA G‐Quadruplex formed in the HIV‐1 Promoter and Comparative Binding Studies

L Bonnat, L Bar, B Génnaro, H Bonnet… - … A European Journal, 2017 - Wiley Online Library
G‐rich DNA oligonucleotides derived from the promoter region of the HIV‐1 long terminal
repeat (LTR) were assembled onto an addressable cyclopeptide platform through …

Targeting conformational activation of CDK2 kinase

M Pellerano, S Tcherniuk, C Perals… - Biotechnology …, 2017 - Wiley Online Library
Cyclin‐dependent kinases constitute attractive pharmacological targets for cancer
therapeutics, yet inhibitors in clinical trials target the ATP‐binding pocket of the CDK and …

Synthesis and structure of dihydroberberine nitroaryl derivatives–potential ligands for G-quadruplexes

ON Burov, SV Kurbatov, ME Kletskii… - Chemistry of …, 2017 - Springer
A method was developed for the synthesis of dihydroberberine nitroaryl derivatives on the
basis of dihydroberberine reactions with aromatic electrophiles (picryl chloride, 4-chloro-7 …

Синтез и строение нитроарильных производных дигидроберберина–потенциальных лигандов G-квадруплексов

ОН Буров, МЕ Клецкий, Д Александр… - Chemistry of …, 2017 - 5.179.29.131
Разработан метод синтеза нитроарильных производных дигидроберберина,
заключающийся во взаимодействии дигидроберберина и ароматических …

Synthèse et étude d'ADN et d'ARN G-quadruplexes à topologies contrôlées. Applications pour la caractérisation et la sélection de ligands

L Bonnat - 2017 - theses.hal.science
Les acides nucléiques riches en guanines ou en cytosines peuvent se replier sur eux-
mêmes et former des systèmes tétramériques tels que les G-quadruplexes (G4) ou les i …

[PDF][PDF] Design and Synthesis of Benzofused Biaryl Polyamides as G-Quadruplex Targeting Agents

K Nahar - 2017 - kclpure.kcl.ac.uk
Guanine-rich nucleic acids can fold into distinctive four-stranded G-quadruplex structures
which are found in telomeric DNA repeats, as well as in sequences in promoter and other …