Reactive oxygen species (ROS) act as signaling molecules that control physiological
processes, including cell adaptation to stress. Redox signaling via ROS has quite recently …

Background: The purpose of this meta-analysis was to determine if uric acid-lowering
therapy is associated with a decrease in blood pressure (BP) and serum creatinine levels …

Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved
in the pathogenesis of different systemic disorders that affect cardiovascular and renal …

Epidemiological studies indicate that hyperuricaemia is an independent risk factor for
cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity …

Whether to treat hyperuricemia uncomplicated by articular gout, urolithiasis, or uric acid
nephropathy is an exercise in clinical judgment and universal agreement is lacking. Patients …

A high-fructose diet is shown to induce salt-sensitive hypertension, but the underlying
mechanism largely remains unknown. The major goal of the present study was to test the …

Several epidemiological studies have demonstrated the existence of a correlation between
high serum uric acid (SUA) levels, hypertension, and chronic kidney disease (CKD). Xantine …

Objective To assess the effect of allopurinol use on the risk of incident atrial fibrillation (AF)
in the elderly. Methods We used the 5% random Medicare Claims data from 2006 to 2012 to …

BACKGROUND It is uncertain whether high-baseline uric acid (UA) or change in UA
concentration over time is related to development of incident hypertension. To investigate …

Background Elevated uric acid concentration is associated with higher rates of
cardiovascular (CV) morbidity and mortality in the general population. It is not known …