Self-micro emulsifying drug delivery systems (SMEDDS): a review on physico-chemical and biopharmaceutical aspects

SD Maurya, RKK Arya, G Rajpal… - Journal of Drug Delivery …, 2017 - jddtonline.info
Nearly 40% of new drug candidates exhibit low solubility in water, which is a challenge in
development of optimum oral solid dosage form in terms of formulation design and …

Enhancing biopharmaceutical performance of an anticancer drug by long chain PUFA based self-nanoemulsifying lipidic nanomicellar systems

RK Khurana, S Beg, AJ Burrow, RK Vashishta… - European Journal of …, 2017 - Elsevier
The aim of this study was to develop polyunsaturated fatty acid (PUFA) long chain glyceride
(LCG) enriched self-nanoemulsifying lipidic nanomicelles systems (SNELS) for augmenting …

Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation

A Parikh, K Kathawala, CC Tan, S Garg, XF Zhou - Drug delivery, 2017 - Taylor & Francis
Edaravone (EDR) is a well-recognized lipophilic free radical scavenger for diseases
including neurodegenerative disease, cardiovascular disease, and cancer. However, its oral …

Formulation and evaluation of solid self-microemulsifying drug delivery system of chlorthalidone by spray drying technology

JK Madagul, DR Parakh, RS Kumar… - Drying …, 2017 - Taylor & Francis
The main objective of this study was to prepare a solid self-microemulsifying drug delivery
system (S-SMEDDS) by spray drying liquid SMEDDS with an inert solid carrier Aerosil 200 …

[HTML][HTML] SMEDDS of pioglitazone: Formulation, in-vitro evaluation and stability studies

V Pandey, S Kohli - Future Journal of Pharmaceutical Sciences, 2017 - Elsevier
Over past many decades solubility had always been a major concern in leading to high
intrasubject/intersubject variability, lack of dose proportionality and ultimately low …

Selection of excipients for the development of carvedilol loaded lipid-based drug delivery systems

LAD Silva, ER Cintra, ECP Alonso, GL Alves… - Journal of thermal …, 2017 - Springer
Carvedilol (CARV) is a widely used drug, which has shown low oral bioavailability. Lipid-
based drug delivery systems (LBDDS) appear as promising alternatives to overcome CARV …

Correlating in vitro solubilization and supersaturation profiles with in vivo exposure for lipid based formulations of the CETP inhibitor CP-532,623

CL McEvoy, NL Trevaskis, OM Feeney… - Molecular …, 2017 - ACS Publications
Lipid based formulations (LBFs) are a promising formulation strategy for many poorly water-
soluble drugs and have been shown previously to enhance the oral exposure of CP …

Preparation and evaluation of Vinpocetine self-emulsifying pH gradient release pellets

M Liu, S Zhang, S Cui, F Chen, L Jia, S Wang, X Gai… - Drug Delivery, 2017 - Taylor & Francis
The main objective of this study was to develop a pH gradient release pellet with self-
emulsifying drug delivery system (SEDDS), which could not only improve the oral …

Storage stability of bivalirudin: hydrophilic versus lipophilic solutions

O Zupančič, JA Grießinger, HT Lam… - Journal of …, 2017 - Elsevier
It was the aim of this study to incorporate a model peptide bivalirudin in self-emulsifying drug
delivery system (SEDDS) and compare its storage stability with conventional aqueous …

Lipid based formulation approach for BCS class-II drug: Modafinil in the treatment of ADHD

H Tandel, D Shah, J Vanza, A Misra - Journal of Drug Delivery Science and …, 2017 - Elsevier
The aim of study was to formulate self-microemulsifying drug delivery systems for modafinil.
It was also an objective to optimize formulation parameters and evaluate developed …